p53 Family and Cellular Stress Responses in Cancer

p53 Family and Cellular Stress Responses in Cancer

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to cell-cycle arrest and promotes DNA repair or induces apoptosis via several pathways. p63 and p73 are structural homologs of p53 that can act similarly to the protein and also hold functions distinct from p53. Today m...

Cellular Stress Responses in Cancer and Cancer Therapy

In response to stress, cells activate so-called checkpoints – complex signaling pathways that induce a plethora of cellular outcomes. Checkpoints primarily initiate cell cycle arrest to provide the cell with time to repair the damage. However, if the damage is too severe then cells can permanently arrest the cell cycle (senescence) or trigger cell death, thereby preventing the transmission of g...

Initiating Cellular Stress Responses

The phosphoinositide 3-kinase related kinases (PIKKs) mediate responses to diverse stresses, including DNA double-strand breaks (DSBs), abnormal replication fork progression, the recognition of premature termination codons in mRNAs, and inadequate nutrient availability. Rigorous control of these kinases limits cellular damage and promotes cell viability in the presence of stress. Control mechan...

Cellular Stress Responses

p53 -Dependent and -Independent Nucleolar Stress Responses

The nucleolus has emerged as a cellular stress sensor and key regulator of p53-dependent and -independent stress responses. A variety of abnormal metabolic conditions, cytotoxic compounds, and physical insults induce alterations in nucleolar structure and function, a situation known as nucleolar or ribosomal stress. Ribosomal proteins, including RPL11 and RPL5, become increasingly bound to the ...